Description: Nitrates Updated Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Current Use in Angina, Ischemia, Infarction and Failure Author(s): Udho Thadani, Lionel H. Opie Format: Paperback Publisher: Springer-Verlag New York Inc., United States Imprint: Springer-Verlag New York Inc. ISBN-13: 9781461284345, 978-1461284345 Synopsis Nitrates remain among the most commonly used therapeutic agents in cardiology. That they can re lieve pain in angina pectoris has been known at least since 1867, when Lauder Brunton described their clinical use. Now, almost 130 years later, we are constantly learning more about their optimal use in anginal syndromes. For example, there is no doubt that nitrate tolerance occurs, but equally no doubt that certain drug dosages help to attenuate such toler ance. Thus, our understanding of nitrate tolerance has been taken further by the advent of new nitrate preparations and by studies at a basic science level. The current intense interest in nitrates has been rekindled by the growing emphasis on the role of the endothelium in the production of nitric oxide, a basic cardiovascular regulator. If nitric oxide is vasodilator and protects the vascular endothelium, then nitrates should also have similar properties. Hence this book starts off with the role of the endothelium and ni trates in vasodilation. Next, the mechanisms of ac tion of nitrates are considered with emphasis on the role of cyclic GMP. The chief limitation to the use of nitrates lies in nitrate tolerance. After carefully looking at all the evidence, the authors of the third chapter conclude that the mechanism is likely to be multifactorial. The mechanism responsible for the tolerance still remains unknown. In vitro tolerance may be due to enhanced production of vascular superoxide [1].
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Book Title: Nitrates Updated
Number of Pages: 226 Pages
Publication Name: Nitrates Updated: Current Use in Angina, Ischemia, Infarction and Failure
Language: English
Publisher: Springer-Verlag New York Inc.
Item Height: 254 mm
Subject: Medicine
Publication Year: 2011
Type: Textbook
Item Weight: 453 g
Author: Udho Thadani, Lionel H. Opie
Item Width: 178 mm
Format: Paperback
