Meta-Analysis of Controlled Clinical Trials by Anne Whitehead (English) Hardcove

Description: FREE SHIPPING UK WIDE Meta-Analysis of Controlled Clinical Trials by Anne Whitehead Meta--analysis is one of the main statistical methods used in clinical trials. Previous accounts of meta--analysis have given the impression that the topic is a series of separate techniques. This book provides a unified approach, developing the subject from mathematical theory through to practical discussions of implementation. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Over the last twenty years there has been a dramatic upsurge in the application of meta-analysis to medical research. This has mainly been due to greater emphasis on evidence-based medicine and the need for reliable summaries of the vast and expanding volume of clinical research. At the same time there have been great strides in the development and refinement of the associated statistical methodology. This book describes the planning, conduct and reporting of a meta-analysis as applied to a series of randomized controlled clinical trials. The various approaches are presented within a general unified framework.Meta-analysis techniques are described in detail, from their theoretical development through to practical implementation.Each topic discussed is supported by detailed worked examples.A comparison of fixed and random effects approaches is included, as well as a discussion of Bayesian methods and cumulative meta-analysis.Fully documented programs using standard statistical procedures in SAS are available on the Web. Ideally suited for practising statisticians and statistically-minded medical professionals, the book will also be of use to graduate students of medical statistics. The book is a self-contained and comprehensive account of the subject and an essential purchase for anyone involved in clinical trials. Back Cover Over the last twenty years there has been a dramatic upsurge in the application of meta-analysis to medical research. This has mainly been due to greater emphasis on evidence-based medicine and the need for reliable summaries of the vast and expanding volume of clinical research. At the same time there have been great strides in the development and refinement of the associated statistical methodology. This book describes the planning, conduct and reporting of a meta-analysis as applied to a series of randomized controlled clinical trials. The various approaches are presented within a general unified framework. Meta-analysis techniques are described in detail, from their theoretical development through to practical implementation. Each topic discussed is supported by detailed worked examples. A comparison of fixed and random effects approaches is included, as well as a discussion of Bayesian methods and cumulative meta-analysis. Fully documented programs using standard statistical procedures in SAS are available on the Web. Ideally suited for practising statisticians and statistically-minded medical professionals, the book will also be of use to graduate students of medical statistics. The book is a self-contained and comprehensive account of the subject and an essential purchase for anyone involved in clinical trials. Flap Over the last twenty years there has been a dramatic upsurge in the application of meta-analysis to medical research. This has mainly been due to greater emphasis on evidence-based medicine and the need for reliable summaries of the vast and expanding volume of clinical research. At the same time there have been great strides in the development and refinement of the associated statistical methodology. This book describes the planning, conduct and reporting of a meta-analysis as applied to a series of randomized controlled clinical trials. The various approaches are presented within a general unified framework. Meta-analysis techniques are described in detail, from their theoretical development through to practical implementation. Each topic discussed is supported by detailed worked examples. A comparison of fixed and random effects approaches is included, as well as a discussion of Bayesian methods and cumulative meta-analysis. Fully documented programs using standard statistical procedures in SAS are available on the Web. Ideally suited for practising statisticians and statistically-minded medical professionals, the book will also be of use to graduate students of medical statistics. The book is a self-contained and comprehensive account of the subject and an essential purchase for anyone involved in clinical trials. Author Biography Anne Whitehead is Senior Lecturer in Modern and Contemporary Literature at Newcastle University, UK. She is the author of many books. Table of Contents Introduction Protocol development Estimating the treatment difference in an individual trial Combining estimates of a treatment difference across trials Meta-analysis using individual patient data Dealing with heterogeneity Presentation and interpretation of results Selection bias Dealing with non-standard datasets Inclusion of trials with different study designs A Bayesian approach to meta-analysis Sequential methods for meta-analysis Appendix Methods of estimation and hypothesis testing Review "…highly recommended as essential reading for medical statisticians…" (Short Book Reviews, April 2003) "...comprehensive and well illustrated contribution to the subject...useful for graduate students of medical statistics..." (Statistics in Medicine, Vol 23(3), 15 February 2004) Long Description Over the last twenty years there has been a dramatic upsurge in the application of meta-analysis to medical research. This has mainly been due to greater emphasis on evidence-based medicine and the need for reliable summaries of the vast and expanding volume of clinical research. At the same time there have been great strides in the development and refinement of the associated statistical methodology. This book describes the planning, conduct and reporting of a meta-analysis as applied to a series of randomized controlled clinical trials. The various approaches are presented within a general unified framework. Meta-analysis techniques are described in detail, from their theoretical development through to practical implementation. Each topic discussed is supported by detailed worked examples. A comparison of fixed and random effects approaches is included, as well as a discussion of Bayesian methods and cumulative meta-analysis. Fully documented programs using standard statistical procedures in SAS are available on the Web. Ideally suited for practising statisticians and statistically-minded medical professionals, the book will also be of use to graduate students of medical statistics. The book is a self-contained and comprehensive account of the subject and an essential purchase for anyone involved in clinical trials. Review Text "?highly recommended as essential reading for medical statisticians?" (Short Book Reviews, April 2003) "...comprehensive and well illustrated contribution to the subject...useful for graduate students of medical statistics..." (Statistics in Medicine, Vol 23(3), 15 February 2004) Review Quote "...highly recommended as essential reading for medical statisticians..." (Short Book Reviews, April 2003) "...comprehensive and well illustrated contribution to the subject...useful for graduate students of medical statistics..." (Statistics in Medicine, Vol 23(3), 15 February 2004) Feature Growing importance of evidence-based techniques. Increased demand has placed new emphasis on meta-analysis. Aimed specifically for those involved with clinical trials. Methodology presented is illustrated with relevant examples. Includes computer programs (written in SAS) available on an accompanying Web site. Details ISBN0471983705 Author Anne Whitehead Short Title META ANALYSIS OF CONTROLLED CL Language English ISBN-10 0471983705 ISBN-13 9780471983705 Media Book Format Hardcover Illustrations Yes Year 2002 Edition 1st Imprint John Wiley & Sons Inc Place of Publication New York Country of Publication United States DOI 10.1604/9780471983705 Series Number 7 UK Release Date 2002-07-16 AU Release Date 2002-07-16 NZ Release Date 2002-07-16 US Release Date 2002-07-16 Pages 352 Publisher John Wiley & Sons Inc Series Statistics in Practice Publication Date 2002-07-16 DEWEY 615.19 Audience Undergraduate We've got this At The Nile, if you're looking for it, we've got it. 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